Article

Sirt1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis

2025-07-31

Abstract excerpt

<title>Abstract</title> <p>Aging is a major contributor to the escalating prevalence of heart failure (HF). Ferroptosis has been implicated in age-related disorders and cardiovascular diseases.The role of ferroptosis in age-related HF and the underlying mechanisms remain ambiguous. Herein, we found that aging rats displayed compromised cardiac function, with molecular characteristics indicative of ferroptosis, in...

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Literature Corpus work: 1fd94b39-8946-56d4-a1fd-53eea9dfb2c1
DOI: 10.21203/rs.3.rs-7140279/v1

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