Article
An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
Circulation research - 7 Jul 2023
Dai Yuanyuan, Ignatyeva Nadezda, Xu Hang, Wali Ruheen, Toischer Karl, Brandenburg Sören, Lenz Christof, Pronto Julius, Fakuade Funsho E, Sossalla Samuel, Zeisberg Elisabeth M, Janshoff Andreas, Kutschka Ingo, Voigt Niels, Urlaub Henning, Rasmussen Torsten Bloch, Mogensen Jens, Lehnart Stephan E, Hasenfuss Gerd, Ebert Antje
Abstract excerpt
BACKGROUND: Systemic defects in intestinal iron absorption, circulation, and retention cause iron deficiency in 50% of patients with heart failure. Defective subcellular iron uptake mechanisms that are independent of systemic absorption are incompletely understood. The main intracellular route for iron uptake in cardiomyocytes is clathrin-mediated endocytosis. METHODS: We investigated subcellular iron uptake...
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