Article
Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.
European heart journal - 1 Feb 2017
Haddad Saba, Wang Yong, Galy Bruno, Korf-Klingebiel Mortimer, Hirsch Valentin, Baru Abdul M, Rostami Fatemeh, Reboll Marc R, Heineke Jörg, Flögel Ulrich, Groos Stephanie, Renner André, Toischer Karl, Zimmermann Fabian, Engeli Stefan, Jordan Jens, Bauersachs Johann, Hentze Matthias W, Wollert Kai C, Kempf Tibor
Abstract excerpt
Aims: Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the underlying mechanisms are incompletely understood. Intracellular iron availability is secured by two mRNA-binding iron-regulatory proteins (IRPs), IRP1 and IRP2. We generated mice with a cardiomyocyte-targeted deletion of Irp1 and Irp2 to explore the functional implications of ID in the heart independent of systemic ID...
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