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Article

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

PloS one - 1 Jan 2020

Coassin Stefan, Hermann-Kleiter Natascha, Haun Margot, Wahl Simone, Wilson Rory, Paulweber Bernhard, Kunze Sonja, Meitinger Thomas, Strauch Konstantin, Peters Annette, Waldenberger Melanie, Kronenberg Florian, Lamina Claudia

Abstract excerpt

Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an epigenome-wide analysis of DNA methylation on Lp(a) levels in two population-based studies (total n = 2208). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32343731
DOI: 10.1371/journal.pone.0232073
PMCID: PMC7188291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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