Article
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
The American journal of clinical nutrition - 1 Feb 2016
Ma Yiyi, Follis Jack L, Smith Caren E, Tanaka Toshiko, Manichaikul Ani W, Chu Audrey Y, Samieri Cecilia, Zhou Xia, Guan Weihua, Wang Lu, Biggs Mary L, Chen Yii-Der I, Hernandez Dena G, Borecki Ingrid, Chasman Daniel I, Rich Stephen S, Ferrucci Luigi, Irvin Marguerite Ryan, Aslibekyan Stella, Zhi Degui, Tiwari Hemant K, Claas Steven A, Sha Jin, Kabagambe Edmond K, Lai Chao-Qiang, Parnell Laurence D, Lee Yu-Chi, Amouyel Philippe, Lambert Jean-Charles, Psaty Bruce M, King Irena B, Mozaffarian Dariush, McKnight Barbara, Bandinelli Stefania, Tsai Michael Y, Ridker Paul M, Ding Jingzhong, Mstat Kurt Lohmant, Liu Yongmei, Sotoodehnia Nona, Barberger-Gateau Pascale, Steffen Lyn M, Siscovick David S, Absher Devin, Arnett Donna K, Ordovás José M, Lemaitre Rozenn N
Abstract excerpt
BACKGROUND: DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression. OBJECTIVE: We aimed to explore whether the gene-by-diet interactions on blood lipids act through DNA methylation. DESIGN: We selected 7 SNPs on the basis of predicted relations in fatty acids, methylation, and lipids. We conducted a meta-analysis and a methylation and mediation...
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