Article

Intrinsic higher potency of basal urothelial cells to intermediate and umbrella cells as the cell of origin for bladder cancer

2025-07-03

Abstract excerpt

Transcriptome profiling of bladder cancer has revealed distinct basal-like and luminal-like molecular subtypes, which may be correlated with pathological subtypes of different patient outcomes. However, whether these molecular subtypes originate from the corresponding cell types in the normal urothelium and whether different cells of origin influence bladder cancer progression remain unclear. Here, we conducted ce...

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Literature Corpus work: 655dc802-3fa5-5f67-9c2d-01e6d4e04506
DOI: 10.1101/2025.06.28.662140

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