Article

Cell type composition drives patient stratification in single-cell RNA-seq cohorts

2026-03-31

Abstract excerpt

Early transcriptomic studies demonstrated that unsupervised analysis of bulk gene expression can reveal clinically meaningful patient subgroups. Single-cell RNA sequencing (scRNA-seq) provides high-resolution characterization of cellular heterogeneity and therefore enables more refined patient stratification. Several computational approaches have been proposed to summarize single-cell data into sample-level repres...

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Literature Corpus work: a33aa34e-66e2-5975-ae75-a5869578ea3f
DOI: 10.64898/2026.03.27.714811

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