Article
A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification
23 Apr 2020
Abstract excerpt
Hematopoietic development is spatiotemporally tightly regulated by defined cell-intrinsic and extrinsic modifiers. The role of cytokines has been intensively studied in adult hematopoiesis; however, their role in embryonic hematopoietic specification remains largely unexplored. Here, we used induced pluripotent stem cell (iPSC) technology and established a 3-dimensional, organoid-like differentiation system...
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