Generating human hematopoietic stem cells <i>in vitro</i> –exploring endothelial to hematopoietic transition as a portal for stemness acquisition

Abstract excerpt

Advances in cellular reprogramming technologies have created alternative platforms for the production of blood cells, either through inducing pluripotency in somatic cells or by way of direct conversion of nonhematopoietic cells into blood cells. However, de novo generation of hematopoietic stem cells (HSCs) with robust and sustained multilineage engraftment potential remains a significant challenge. Hemogenic...

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