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Article

Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.

The Journal of biological chemistry - 24 Feb 2012

Kim Kiyoung, Kim Song-Hee, Kim Jaekwang, Kim Heuijong, Yim Jeongbin

Abstract excerpt

A loss-of-function mutation in the gene parkin causes a common neurodegenerative disease that may be caused by mitochondrial dysfunction. Glutathione S-transferase Omega (GSTO) is involved in cell defense mechanisms, but little is known about the role of GSTO in the progression of Parkinson disease. Here, we report that restoration of Drosophila GSTO1 (DmGSTO1), which is down-regulated in parkin mutants,...

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Source

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Identifiers

PMID: 22219196
DOI: 10.1074/jbc.M111.291179
PMCID: PMC3307323

Genes

GSTO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.PMID 22219196Read ↗

Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila.Semantic proximity Read ↗

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.Semantic proximity Read ↗

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The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.Semantic proximity Read ↗

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.Semantic proximity Read ↗

Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease.Semantic proximity Read ↗

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in DrosophilaSemantic proximity Read ↗

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondriaSemantic proximity Read ↗

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.Semantic proximity Read ↗

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The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1).Semantic proximity Read ↗

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