Article
Overexpressed PERK suppresses the neurodegenerative phenotypes in PINK1B9 flies by enhancing mitochondrial function.
Neurochemistry international - 1 Nov 2020
Cui Ying, Wen Xueyi, Nan Yuyu, Xiang Guoliang, Wei Zaiwa, Wei Lili, Xia Yang, Li Qinghua
Abstract excerpt
PTEN-induced putative kinase 1 (PINK1) mutation induces autosomal recessive Parkinson's Disease (PD), mitochondrial dysfunction is the central pathogenic process. However, more and more studies presented the bulk of the damage to neurons with mitochondrial dysfunction stems from the endoplasmic reticulum (ER) stress. In mitochondria damaged PINK1B9 fly model how protein kinase RNA-like ER kinase (PERK) arm of ER...
Topics
- Animals
- Animals, Genetically Modified
- Drosophila
- Drosophila Proteins
- Gene Expression
- Male
- Mitochondria
- Neurodegenerative Diseases
- Phenotype
- Protein Serine-Threonine Kinases