Article

The dysregulated Pink1 <sup>-</sup> Drosophila mitochondrial proteome is partially corrected with exercise

2021-01-07

Abstract excerpt

One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may enhance synaptic plasticity, protect against neuro-inflammation and modulate L-Dopa regulated signalling pathways. We explored the effects of exercise on Pink1 deficie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 461978ab-f396-5099-998b-a888aded67e7
DOI: 10.1101/2021.01.06.425659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The dysregulated Pink1 <sup>-</sup> Drosophila mitochondrial proteome is partially corrected with exerciseDOI 10.1101/2021.01.06.425659Read

The dysregulated Pink1- Drosophila mitochondrial proteome is partially corrected with exercise.Semantic proximity Read

Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes.Semantic proximity Read

Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.Semantic proximity Read

Basal mitophagy is widespread in <i>Drosophila</i> but minimally affected by loss of Pink1 or parkinSemantic proximity Read

The Metabolome of <i>Drosophila</i> Reveals Exercise-Induced Stress and Anti-Inflammatory ResponseSemantic proximity Read

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin modelsSemantic proximity Read

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin.Semantic proximity Read

Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's diseaseSemantic proximity Read

Metabolic alterations in a <i>Drosophila</i> model of Parkinson’s disease based on <i>DJ-1</i> deficiencySemantic proximity Read

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.Semantic proximity Read

Insights into dentatorubral-pallidoluysian atrophy from a new Drosophila model of diseaseSemantic proximity Read

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinSemantic proximity Read