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Article

Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.

International journal of oncology - 1 May 2020

Yin Yanan, Che Kui, Hu Jianxia, Hua Hui, Dong Anbing, Wang Jueru, Yu Jiarui, Zhang Qing, Zhao Shihua, Zhao Yuhang, Wang Ping, Wang Fei, Wang Yangang, Chi Jingwei, Sun Wenhai

Abstract excerpt

Ribosomal S6 kinase 4 (RSK4) is a putative tumor suppressor gene which is inactivated by epigenetic events in a number human malignancies; however, its role in papillary thyroid carcinoma (PTC) remains largely unknown. The aim of this study was to explore the methylation status of the RSK4 promoter in PTC, and to determine its potential role in thyroid carcinogenesis. Reverse transcription‑quantitative PCR...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Proto-Oncogene Proteins B-raf

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Share to Thyroid Cancer, Papillary

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Source

Identifiers

PMID: 32319586
DOI: 10.3892/ijo.2020.4999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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