Article
Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer.
International journal of cancer - 15 Nov 2006
Hu Shuiying, Liu Dingxie, Tufano Ralph P, Carson Kathryn A, Rosenbaum Eli, Cohen Yoram, Holt Elizabeth H, Kiseljak-Vassiliades Katja, Rhoden Kerry J, Tolaney Sara, Condouris Stephen, Tallini Giovanni, Westra William H, Umbricht Christopher B, Zeiger Martha A, Califano Joseph A, Vasko Vasily, Xing Mingzhao
Abstract excerpt
The role of aberrant tumor suppressor gene methylation in the aggressiveness of papillary thyroid cancer (PTC) has not been documented. By showing promoter methylation-induced gene silencing in PTC-derived cell lines, we first demonstrated the functional consequence of methylation of several recently identified tumor suppressor genes, including those for tissue inhibitor of metalloproteinase-3 (TIMP3), SLC5A8,...
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