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Article

Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness.

Oncotarget - 3 Jan 2017

Zhang Tao, Shen Xiaopei, Liu Rengyun, Zhu Guangwu, Bishop Justin, Xing Mingzhao

Abstract excerpt

How the BRAF V600E mutation promotes the pathogenesis and aggressiveness of papillary thyroid cancer (PTC) is not completely understood. Here we explored a novel mechanism involving WASP interacting protein family member 1 (WIPF1). In PTC tumors, compared with the wild-type BRAF, BRAF V600E was associated with over-expression and hypomethylation of the WIPF1 gene. In thyroid cancer cell lines with wild-type BRAF,...

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Source

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Identifiers

PMID: 27863429
DOI: 10.18632/oncotarget.13400
PMCID: PMC5352205

Genes

BRAF
WIPF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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