Article
Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model.
Molecular cancer - 13 Mar 2007
Cahill Susanne, Smyth Paul, Denning Karen, Flavin Richard, Li Jinghuan, Potratz Astrid, Guenther Simone M, Henfrey Richard, O'Leary John J, Sheils Orla
Abstract excerpt
BACKGROUND: microRNAs (miRNAs) are a group of non-coding single stranded RNAs measuring approximately 22 nucleotides in length that have been found to control cell growth, differentiation and apoptosis. They negatively regulate target genes and have recently been implicated in tumourigenesis. Furthermore, miRNA expression profiling correlates with various cancers, with these genes thought to act as both tumour...
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