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Article

Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.

Journal of neurology - 1 Aug 2020

Gersel Stokholm Morten, Garrido Alicia, Tolosa Eduardo, Serradell Mónica, Iranzo Alex, Østergaard Karen, Borghammer Per, Møller Arne, Parbo Peter, Stær Kristian, Brooks David J, Martí Maria José, Pavese Nicola

Abstract excerpt

Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of...

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Identifiers

PMID: 32318850
DOI: 10.1007/s00415-020-09830-3
PMCID: PMC7359140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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