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Article

The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.

The Journal of biological chemistry - 1 Jul 2023

Pajarillo Edward, Kim Sanghoon, Digman Alexis, Dutton Matthew, Son Deok-Soo, Aschner Michael, Lee Eunsook

Abstract excerpt

Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing common symptoms with Parkinson's disease (PD). Studies have shown that Mn can increase the expression and activity of leucine-rich repeat kinase 2 (LRRK2), leading to inflammation and toxicity in microglia. LRRK2 G2019S mutation also elevates LRRK2 kinase activity. Thus, we tested if Mn-increased microglial LRRK2 kinase is...

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Identifiers

PMID: 37269951
DOI: 10.1016/j.jbc.2023.104879
PMCID: PMC10331485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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