Article
Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene.
Annals of neurology - 1 Mar 2001
Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius L J, Lenz O, Vieregge P, Herholz K, Heiss W D, Pramstaller P P
Abstract excerpt
A kindred from South Tyrol (northern Italy) with familial, adult-onset parkinsonism of pseudo-dominant inheritance and mutations in the parkin gene was recently described. To gain insight into basal ganglia dysfunction in this form of hereditary parkinsonism, positron emission tomography (PET) with 18-fluorodopa (FDOPA) and 11C-raclopride (RAC) was performed in 5 affected family members and 5 asymptomatic...
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