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Article

Brain Microglial Activation Increased in Glucocerebrosidase (GBA) Mutation Carriers without Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2021

Mullin Stephen, Stokholm Morten Gersel, Hughes Derralyn, Mehta Atul, Parbo Peter, Hinz Rainer, Pavese Nicola, Brooks David J, Schapira Anthony H V

Abstract excerpt

BACKGROUND: Glucocerebrosidase gene mutations are a common genetic risk factor for Parkinson's disease. They exhibit incomplete penetrance. The objective of the present study was to measure microglial activation and dopamine integrity in glucocerebrosidase gene mutation carriers without Parkinson's disease compared to controls. METHODS: We performed PET scans on 9 glucocerebrosidase gene mutation carriers without...

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Identifiers

PMID: 33278043
DOI: 10.1002/mds.28375
PMCID: PMC8048428

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