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Article

miRNA gene mutations commonly disrupt the proper functioning of miRNA genes.

Science advances - 20 Feb 2026

Machowska Magdalena, Szostak Natalia, Tire Adrian, Wegorek Wladyslaw, Suszynska Malwina, Kajdasz Arkadiusz, Galka-Marciniak Paulina, Philips Anna, Kozlowski Piotr

Abstract excerpt

A growing number of mutations are being identified in the noncoding genome, including microRNA (miRNA) genes; however, little is known about the consequences of these mutations and how harmful they are to the functioning of miRNA genes. To evaluate the effects of miRNA gene mutations, we took advantage of a large collection of somatic mutations identified in miRNA genes in >10,000 The Cancer Genome Atlas cancer...

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PMID: 41706844
DOI: 10.1126/sciadv.aea6079
PMCID: PMC12915624

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