Article
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Nature cell biology - 1 Aug 2015
Lu Wei-Yu, Bird Thomas G, Boulter Luke, Tsuchiya Atsunori, Cole Alicia M, Hay Trevor, Guest Rachel V, Wojtacha Davina, Man Tak Yung, Mackinnon Alison, Ridgway Rachel A, Kendall Timothy, Williams Michael J, Jamieson Thomas, Raven Alex, Hay David C, Iredale John P, Clarke Alan R, Sansom Owen J, Forbes Stuart J
Abstract excerpt
Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic progenitor cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe a mouse model where the E3 ubiquitin ligase Mdm2 is inducibly deleted in more than 98% of hepatocytes, causing apoptosis, necrosis and senescence with nearly all hepatocytes...
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