Article

An Essential Role for <i>Argonaute 2</i> in EGFR-KRAS Signaling in Pancreatic Cancer Development

2017-11-30

Abstract excerpt

KRAS and EGFR are known essential mediators of pancreatic cancer development. In addition, KRAS and EGFR have both been shown to interact with and perturb the function of Argonaute 2 (AGO2), a key regulator of RNA-mediated gene silencing. Here, we employed a genetically engineered mouse model of pancreatic cancer to define the effects of conditional loss of AGO2 in KRAS G12D -driven pancreatic cancer. Genetic ab...

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Literature Corpus work: 56a260ea-5ff5-5093-b49a-fcdca00194cf
DOI: 10.1101/227264

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