Article
Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis.
Hepatology (Baltimore, Md.) - 1 Mar 2016
Jung Kwang Hwa, Zhang Jing, Zhou Chong, Shen Hong, Gagea Mihai, Rodriguez-Aguayo Cristian, Lopez-Berestein Gabriel, Sood Anil K, Beretta Laura
Abstract excerpt
UNLABELLED: The death rate from hepatocellular carcinoma (HCC) is increasing, and liver cancer is the second leading cause of cancer-related mortality worldwide. Most patients with HCC have underlying liver cirrhosis and compromised liver function, limiting treatment options. Cirrhosis is associated with cell dedifferentiation and expansion of hepatocholangiolar progenitor cells. We identified a microRNA...
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