Article
HLA-G whole gene amplification reveals linkage disequilibrium between the HLA-G 3'UTR and coding sequence.
HLA - 1 Aug 2020
Drabbels Jos J M, Welleweerd Robert, van Rooy Inge, Johnsen Guro M, Staff Anne Cathrine, Haasnoot Geert W, Westerink Nienke, Claas Frans H J, Rozemuller Erik, Eikmans Michael
Abstract excerpt
Polymorphic sites in the HLA-G gene may influence expression and function of the protein. Knowledge of the association between high-resolution HLA-G alleles and 3-prime untranslated (3'UTR) haplotypes is useful for studies on the role of HLA-G in transplantation, pregnancy, and cancer. We developed a next generation sequencing (NGS)-based typing assay enabling full phasing over the whole HLA-G gene sequence with...
Topics
- 3' Untranslated Regions
- Alleles
- Child
- Female
- Gene Amplification
- Gene Frequency
- HLA-G Antigens
- Haplotypes
- Humans
- Infectious Disease Transmission, Vertical