Article
The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes.
Genes and immunity - 1 Mar 2010
Castelli E C, Mendes-Junior C T, Deghaide N H S, de Albuquerque R S, Muniz Y C N, Simões R T, Carosella E D, Moreau P, Donadi E A
Abstract excerpt
The HLA-G gene is predominantly expressed at the maternal-fetal interface. It has been associated with maternal-fetal tolerance and in the inhibition of cytotoxic T lymphocyte and natural killer cytolytic functions. At least two variations in the 3'untranslated region (UTR) of HLA-G locus are associated with HLA-G expression levels, the 14-bp deletion/insertion polymorphism and the +3142 single-nucleotide...
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