Article
Certain haplotypes of the 3'-UTR region of the HLA-G gene are linked to breast cancer.
British journal of biomedical science - 1 Apr 2021
Haghi M, Ranjbar M, Karari K, Samadi-Miandoab S, Eftekhari A, Hosseinpour-Feizi M A
Abstract excerpt
Background: Human leukocyte antigen G belongs to the family of non-classical HLA class I genes, its expression considered an important immune escape mechanism of cancer cells. The polymorphisms in the 3'-untranslated region (UTR) region of HLA-G influence the magnitude of the protein by modulating HLA-G mRNA stability. We hypothesised links between any of eight (UTR) single nucleotide polymorphisms (SNPs) and...
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