Article
Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis.
Human immunology - 1 Oct 2018
de Almeida Bibiana Sgorla, Muniz Yara Costa Netto, Prompt Alice Heidrich, Castelli Erick C, Mendes-Junior Celso Teixeira, Donadi Eduardo Antonio
Abstract excerpt
BACKGROUND: HLA-G is an immune checkpoint molecule. Since a differential molecule expression has been reported even for healthy individuals, many studies have focused on polymorphisms at HLA-G regulatory regions, particularly the 3' untranslated region (3'UTR). The presence/absence of a 14-bp sequence was the first polymorphism described and it is the most studied in association between HLA-G and disorders....
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