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Article

Adaptive Laboratory Evolution and Reverse Engineering of Single-Vitamin Prototrophies in Saccharomyces cerevisiae.

Applied and environmental microbiology - 2 Jun 2020

Perli Thomas, Moonen Dewi P I, van den Broek Marcel, Pronk Jack T, Daran Jean-Marc

Abstract excerpt

Quantitative physiological studies on Saccharomyces cerevisiae commonly use synthetic media (SM) that contain a set of water-soluble growth factors that, based on their roles in human nutrition, are referred to as B vitamins. Previous work demonstrated that in S. cerevisiae CEN.PK113-7D, requirements for biotin were eliminated by laboratory evolution. In the present study, this laboratory strain was shown to...

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PMID: 32303542
DOI: 10.1128/AEM.00388-20
PMCID: PMC7267190

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