Article
Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.
Molecular systems biology - 1 Oct 2024
Ghiaci Payam, Jouhten Paula, Martyushenko Nikolay, Roca-Mesa Helena, Vázquez Jennifer, Konstantinidis Dimitrios, Stenberg Simon, Andrejev Sergej, Grkovska Kristina, Mas Albert, Beltran Gemma, Almaas Eivind, Patil Kiran R, Warringer Jonas
Abstract excerpt
Adaptive Laboratory Evolution (ALE) of microorganisms can improve the efficiency of sustainable industrial processes important to the global economy. However, stochasticity and genetic background effects often lead to suboptimal outcomes during laboratory evolution. Here we report an ALE platform to circumvent these shortcomings through parallelized clonal evolution at an unprecedented scale. Using this platform,...
Topics
- Wine
- Fermentation
- Phenotype
- Saccharomyces cerevisiae
- Clonal Evolution
- Directed Molecular Evolution