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Article

APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans.

The Journal of allergy and clinical immunology - 1 Nov 2020

Yeh Tzu-Wen, Okano Tsubasa, Naruto Takuya, Yamashita Motoi, Okamura Miko, Tanita Kay, Du Likun, Pan-Hammarström Qiang, Mitsuiki Noriko, Okada Satoshi, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro

Abstract excerpt

BACKGROUND: Interactions between the tumor necrosis factor (TNF) ligand superfamily and TNF receptor superfamily play critical roles in B-cell development and maturation. A proliferation-inducing ligand (APRIL), a member of the TNF ligand superfamily, is secreted from myeloid cells and known to induce the differentiation of memory B cells to plasmacytes. OBJECTIVE: We sought to elucidate the role of APRIL in...

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Identifiers

PMID: 32298700
DOI: 10.1016/j.jaci.2020.03.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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