Article

Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification

2025-08-24

Abstract excerpt

Sex differences in aortic valve stenosis (AVS) progression have been documented clinically, but the underlying cellular mechanisms that drive sex-dependent calcification in aortic valve tissue remain poorly understood. Here, we harnessed single cell and spatial transcriptomics to investigate mechanisms that drive sex dependent spatial organization of valvular interstitial cell (VIC) and macrophage gene expression...

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Literature Corpus work: bf82af52-cec9-5ef5-9212-81f7f9b5e461
DOI: 10.1101/2025.08.20.671175

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