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QuaDMutNetEx: a method for detecting cancer driver genes with low mutation frequency.

BMC bioinformatics - 23 Mar 2020

Bokhari Yahya, Alhareeri Areej, Arodz Tomasz

Abstract excerpt

BACKGROUND: Cancer is caused by genetic mutations, but not all somatic mutations in human DNA drive the emergence or growth of cancers. While many frequently-mutated cancer driver genes have already been identified and are being utilized for diagnostic, prognostic, or therapeutic purposes, identifying driver genes that harbor mutations occurring with low frequency in human cancers is an ongoing endeavor....

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PMID: 32293263
DOI: 10.1186/s12859-020-3449-2
PMCID: PMC7092414

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