Article
An in vivo platform to select and evolve aggregation-resistant proteins.
Nature communications - 14 Apr 2020
Ebo Jessica S, Saunders Janet C, Devine Paul W A, Gordon Alice M, Warwick Amy S, Schiffrin Bob, Chin Stacey E, England Elizabeth, Button James D, Lloyd Christopher, Bond Nicholas J, Ashcroft Alison E, Radford Sheena E, Lowe David C, Brockwell David J
Abstract excerpt
Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is difficult, and searching for sequences with desired properties is labour-intensive and...
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