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Article

General strategy for the generation of human antibody variable domains with increased aggregation resistance.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2012

Dudgeon Kip, Rouet Romain, Kokmeijer Iris, Schofield Peter, Stolp Jessica, Langley David, Stock Daniela, Christ Daniel

Abstract excerpt

The availability of stable human antibody reagents would be of considerable advantage for research, diagnostic, and therapeutic applications. Unfortunately, antibody variable heavy and light domains (V(H) and V(L)) that mediate the interaction with antigen have the propensity to aggregate. Increasing their aggregation resistance in a general manner has proven to be a difficult and persistent problem, due to the...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22745168
DOI: 10.1073/pnas.1202866109
PMCID: PMC3390889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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