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Article

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.

Proteins - 1 Sept 2011

Perchiacca Joseph M, Bhattacharya Moumita, Tessier Peter M

Abstract excerpt

High-affinity antibodies are critical for numerous diagnostic and therapeutic applications, yet their utility is limited by their variable propensity to aggregate either at low concentrations for antibody fragments or high concentrations for full-length antibodies. Therefore, determining the sequence and structural features that differentiate aggregation-resistant antibodies from aggregation-prone ones is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21732420
DOI: 10.1002/prot.23085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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