Article
Prediction and Reduction of the Aggregation of Monoclonal Antibodies.
Journal of molecular biology - 21 Apr 2017
van der Kant Rob, Karow-Zwick Anne R, Van Durme Joost, Blech Michaela, Gallardo Rodrigo, Seeliger Daniel, Aßfalg Kerstin, Baatsen Pieter, Compernolle Griet, Gils Ann, Studts Joey M, Schulz Patrick, Garidel Patrick, Schymkowitz Joost, Rousseau Frederic
Abstract excerpt
Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve manufacturability, attrition rates, safety, formulation, titers, immunogenicity, and solubility. Here, we explore the potential of predicting and reducing the aggregation propensity of monoclonal antibodies, based on the identification of aggregation-prone...
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