Engineering Strategies to Overcome the Stability-Function Trade-Off in Proteins.

doi:10.1021/acssynbio.1c00512

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Article

Engineering Strategies to Overcome the Stability-Function Trade-Off in Proteins.

ACS synthetic biology - 18 Mar 2022

Teufl Magdalena, Zajc Charlotte U, Traxlmayr Michael W

Abstract excerpt

In addition to its biological function, the stability of a protein is a major determinant for its applicability. Unfortunately, engineering proteins for improved functionality usually results in destabilization of the protein. This so-called stability-function trade-off can be explained by the simple fact that the generation of a novel protein function─or the improvement of an existing one─necessitates the...

Topics

Gene Library
Mutant Proteins
Mutation
Protein Engineering
Proteins

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PMID: 35258287
DOI: 10.1021/acssynbio.1c00512
PMCID: PMC8938945

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