Article
Capturing the primordial Kras mutation initiating urethane carcinogenesis.
Nature communications - 14 Apr 2020
Li Siqi, MacAlpine David M, Counter Christopher M
Abstract excerpt
The environmental carcinogen urethane exhibits a profound specificity for pulmonary tumors driven by an oncogenic Q61L/R mutation in the gene Kras. Similarly, the frequency, isoform, position, and substitution of oncogenic RAS mutations are often unique to human cancers. To elucidate the principles underlying this RAS mutation tropism of urethane, we adapted an error-corrected, high-throughput sequencing approach...
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