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Article

KRAS Alleles: The Devil Is in the Detail.

Trends in cancer - 1 Oct 2017

Haigis Kevin M

Abstract excerpt

KRAS is the most frequently mutated oncogene in cancer and KRAS mutation is commonly associated with poor prognosis and resistance to therapy. Since the KRAS oncoprotein is, as yet, not directly druggable, efforts to target KRAS mutant cancers focus on identifying vulnerabilities in downstream signaling pathways or in stress response pathways that are permissive for strong oncogenic signaling. One aspect of KRAS...

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Identifiers

PMID: 28958387
DOI: 10.1016/j.trecan.2017.08.006
PMCID: PMC5824632

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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