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Article

Decreased tumorigenesis in mice with a Kras point mutation at C118.

Nature communications - 14 Nov 2014

Huang Lu, Carney John, Cardona Diana M, Counter Christopher M

Abstract excerpt

KRAS, NRAS or HRAS genes are mutated to encode an active oncogenic protein in a quarter of human cancers. Redox-dependent reactions can also lead to Ras activation in a manner dependent upon the thiol residue of cysteine 118 (C118). Here, to investigate the effect of mutating this residue on tumorigenesis, we introduce a C118S mutation into the endogenous murine Kras allele and expose the resultant mice to the...

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Source

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Identifiers

PMID: 25394415
DOI: 10.1038/ncomms6410
PMCID: PMC4234187

Genes

HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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