Article
Signaling levels mold the RAS mutation tropism of urethane.
eLife - 17 May 2021
Li Siqi, Counter Christopher M
Abstract excerpt
RAS genes are commonly mutated in human cancer. Despite many possible mutations, individual cancer types often have a 'tropism' towards a specific subset of RAS mutations. As driver mutations, these patterns ostensibly originate from normal cells. High oncogenic RAS activity causes oncogenic stress and different oncogenic mutations can impart different levels of activity, suggesting a relationship between...
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