An ultra-sensitive method to detect mutations in human RAS templates.

Abstract excerpt

The RAS family of small GTPases is mutated in roughly a fifth of human cancers. Hotspot point mutations at codons G12, G13, and Q61 account for 95% of all these mutations, which are well established to render the encoded proteins oncogenic. In humans, this family comprises three genes: HRAS, NRAS, and KRAS. Accumulating evidence argues that oncogenic RAS point mutations may be initiating, as they are often...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Carcinogenesis
• Share to Cell Transformation, Neoplastic