Article
PIG-A gene mutation as a mutagenicity biomarker among coke oven workers.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Aug 2023
Xi Jing, Cao Yiyi, Wang Yanhua, You Xinyue, Liu Weiying, Wang Ting, Yin Jingjing, Ma Junxiang, Wang Zhenjie, Wu Nan, Zhang Xinyu, Duan Huawei, Luan Yang
Abstract excerpt
PIG-A gene mutations can be detected in humans, and PIG-A assays can potentially predict the risk of exposure to carcinogens. However, extensive, population-based studies to validate this are lacking. We studied a cohort of occupational coke oven workers with chronic high exposure to carcinogenic polycyclic aromatic hydrocarbons, which are well-studied genotoxins classified by the IARC as carcinogenic to humans....
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