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Article

TCR+CD4-CD8- (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.

American journal of physiology. Renal physiology - 1 Jun 2020

Gong Jing, Noel Sanjeev, Hsu Joshua, Bush Errol L, Arend Lois J, Sadasivam Mohanraj, Lee Sul A, Kurzhagen Johanna T, Hamad Abdel Rahim A, Rabb Hamid

Abstract excerpt

Acute kidney injury (AKI) due to cisplatin is a significant problem that limits its use as an effective chemotherapeutic agent. T cell receptor+CD4-CD8- double negative (DN) T cells constitute the major T cell population in the human and mouse kidney, express programmed cell death protein (PD)-1, and protect from ischemic AKI. However, the pathophysiological roles of DN T cells in cisplatin-induced AKI is...

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Source

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Identifiers

PMID: 32281417
DOI: 10.1152/ajprenal.00033.2020
PMCID: PMC7311707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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