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Article

Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2011

Sancho-Martínez Sandra M, Piedrafita F Javier, Cannata-Andía Jorge B, López-Novoa José M, López-Hernández Francisco J

Abstract excerpt

Cisplatin is a chemotherapeutic drug whose cytotoxicity is key to its therapeutic and side effects. Nephrotoxicity, mainly due to renal tubular injury, poses its most important therapeutic limitation. Tubular necrosis is derived from epithelial cell death by apoptosis and necrosis in the proximal and distal tubuli. The mode of cell death has been related to drug concentration, with necrosis occurring with high...

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PMID: 21527773
DOI: 10.1093/toxsci/kfr098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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