Article
Human adipose tissue-derived mesenchymal stem cells protect kidneys from cisplatin nephrotoxicity in rats.
American journal of physiology. Renal physiology - 1 May 2012
Kim Jin Hyun, Park Dong Jun, Yun Ji Chul, Jung Myeong Hee, Yeo Hee Dong, Kim Hyun-Jung, Kim Dong Wook, Yang Jung Ill, Lee Gyeong-Won, Jeong Sang-Ho, Roh Gu Seob, Chang Se-Ho
Abstract excerpt
Cisplatin has multiple cellular targets and modes of action that lead to nephrotoxicity. This suggests novel therapies that act at multiple cisplatin target sites may be effective. We tested whether human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) can affect multiple target sites and protect against cisplatin-induced kidney damage. Rats were divided into four groups: control, infused with Ad-MSCs,...
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