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Article

Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update

21 May 2021

Abstract excerpt

Cisplatin is an antineoplastic drug used for the treatment of many solid tumors. Among its various side effects, nephrotoxicity is the most detrimental. In recent years, epigenetic regulation has emerged as a modulatory mechanism of cisplatin-induced nephrotoxicity, involving non-coding RNAs, DNA methylation and histone modifications. These epigenetic marks alter different signaling pathways leading to damage and...

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PMID: 34063951
DOI: 10.3390/ph14060491

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