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Article

Functional TauT Protects Against Acute Kidney Injury

7 May 2009

Abstract excerpt

Nephrotoxicity is common with the use of the chemotherapeutic agent cisplatin, but the cellular mechanisms that modulate the extent of injury are unknown. Cisplatin downregulates expression of the taurine transporter gene (TauT) in LLC-PK1 proximal tubular renal cells, and forced overexpression of TauT protects against cisplatin-induced apoptosis in vitro. Because the S3 segments of proximal tubules are the sites...

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Share to Aldose Reductase and Taurine
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PMID: 19423693
DOI: 10.1681/asn.2008050465

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Functional TauT Protects Against Acute Kidney InjuryPMID 19423693Read ↗

TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model.Semantic proximity Read ↗

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TCR+CD4-CD8- (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.Semantic proximity Read ↗

Histone methyltransferase SET8 aggravates acute kidney injury through activation of p53 and downregulation of PTENSemantic proximity Read ↗

Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury.Semantic proximity Read ↗

MicroRNA-709 Mediates Acute Tubular Injury through Effects on Mitochondrial FunctionSemantic proximity Read ↗

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasisSemantic proximity Read ↗

Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.Semantic proximity Read ↗

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