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Article

The leukotriene B4-leukotriene B4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment.

Kidney international - 1 Jul 2017

Deng Bo, Lin Yuli, Ma Shuai, Zheng Yin, Yang Xuguang, Li Bingji, Yu Wenyan, Xu Qingqing, Liu Tingyan, Hao Chuanming, He Rui, Ding Feng

Abstract excerpt

Cisplatin is an effective chemotherapeutic agent and widely used in treatment of various solid organ malignancies, including head and neck, ovarian, and testicular cancers. However, the induction of acute kidney injury (AKI) is one of its main side effects. Leukotriene B4 receptor 1 (BLT1) mediates the majority of physiological effects of leukotriene B4 (LTB4), a potent lipid chemoattractant generated at...

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Identifiers

PMID: 28318626
DOI: 10.1016/j.kint.2017.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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